To confirm your thought, uninstall the ADWCleaner via CCleaner and clean the registry as well.

Reboot, and reinstall Malwarebytes. Then see if it works...

Have you tried going back using system restore?

 or

sfc /scannow

That was the first thing I did, get rid of ADWCleaner through CCleaner and I did do a system restore. Neither one worked. Another post on the website said Mocrosoft Security Essentials should be uninstalled saying it is the culprit. I don't see how as they both worked fine together up until now. But just to see if that was true I uninstalled MSE, rebooted and tried Mbam again. MSe is not the culprit. Mbam still stops working when I try to update. It even quits during a scan.

Malewarebytes won't run or won't update?

It won't do either one. Another thing I noticed with regards to dialogue boxes. I get this weird two tone blue where it used to be skinned. Not all of them though. This too happened after I ran ADW.

uvah get this fixed yet?

Ross, get MalwareBytes Chameleon. It'll run a cmd prompt, kill anything that's keeping MalwareBytes from installing/running, then it'll install malwarebytes for you, and clean the system.

I just had this same problem on my brother's rig, which was full of malware. He had MWB installed, it wouldn't run. MalwareBytes Chameleon fixed it.

https://www.malwarebytes.org/chameleon/   

Thanks Jim. Gonna run it now. Ran it, it downloaded another mbam, did not install it. Rebooted as it suggested and installed it myself. It did not work. MalwareBytes still will not run.

Hi Uvah I am experiencing the exact same problem already did the same as you verbatim. I don't have adwcleaner so it can't be that I can't figure this one out every time I try to update it just stops responding every single time. I've uninstalled 3 times now and reinstalled and I used Ccleaner every time still to no avail i'am at a loss!! I have also run chameleon as redneckdude said in his reply did not fix mine I have run multiple scans even from safe mode nothing found!! the darn thing just won't run it has to be a conflict somewhere I guess!  

I even went to system repair that took it back to a further restore point. No luck. Even Chameleon didn't work. I are stumped.

Uvah:

Go to your command prompt>Run as Administrator> type in chkdsk /f /r  (space between chkdsk and /f and space between /f and /r).

This will have a 5 step operation. You'll have to reboot for it to start. It'll take some time, so do something while it's doing its thing. It will reair ALL files, etc. That are problematic.

When it's done, it'll reboot into Windows. Hopefully, your problems will have been solved. If not, you may have to do a restore from a backup or a prior point.

Hi DrJBHL I followed your directions as stated in your reply to Uvah Malwarebytes is now working fully and correctly as it should THANK YOU VERY MUCH!!!!!!!!!!!!!!!!!! 

Certainly very glad to hear that, bodadog. 

Yrag taught me that one...and it's never failed me.

Hope it helps Uvah as well.

Uhhh......nope. I let it do its thing. It finished and rebooted and I just tried to run mbam again and no go. I got a little desperate earlier and tried to restore it to factory specs. To my utter dismay, on my Toshiba......the recovery partition is missing. WTF!